Scientific Slides of Lymphangioleiomyomatosis (LAM)

Alpha Actin slide



1. Alpha Actin

2. AML

3. Chylo Thorax

Close LAM Cysts

Expanded Septa

Gross LAM

4. Close Cysts

5. Expanded Septa

6. Gross LAM



Lung Histopath

7. HMB 45


9. Lung Histopath


AML LAM - Figure 3a LAM - Figure 3b
Figure 1
High resolution CT scan of the chest in a patient with LAM.
Note the diffuse replacement of the pulmonary parenchyma with thin walled cysts.
Figure 2
Abdominal CT scan in a LAM patient with an angiomyolipoma. Note the diffuse involvement of the right kidney with an angiomyolipoma. Observe solid and fat density which is characteristic of angiomyolipomas. Abdominal CT scanning is positive in over 75% of patients.

Figure 3a: CT or MRI scanning of the brain is recommended at least once in the lifetime of all S-LAM patients to rule out findings of subclinical TSC such as cortical tubers, subependymal nodules or subependymal giant cell astrocytomas.

Figure 3b: CT scan of the head in two patients with tuberous sclerosis. Subependymal nodules are present in panel a. Cortical tubers are present in panel b.


LAM - Figure 4a LAM - Figure 4b LAM - Figure 4c

Figure 4
Pathological features of LAM. Normal lung tissue with type II cells stained with antibody to surfactant protein A is shown.

Figure 4b is Expanded Septa

In panel b, an alveolar septal wall is expanded with spindle shaped and Epithelioid LAM cells.


Figure 4c is HMB45

HMB 45 staining is shown in panel c.

LAM - Figure 4c

Figure 4d is Lung Histopath

Cystic remodeling of the pulmonary parenchyma is shown in panel d.