LAM Scientific Slides
Scientific Slides of Lymphangioleiomyomatosis (LAM)
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1. Alpha Actin
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2. AML
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3. Chylo Thorax
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4. Close Cysts
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5. Expanded Septa
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6. Gross LAM
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7. HMB 45
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8. HRCT LAM
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9. Lung Histopath
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Figure 1
High resolution CT scan of the chest in a patient with LAM. Note the diffuse replacement of the pulmonary parenchyma with thin walled cysts. |
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Figure 2
Abdominal CT scan in a LAM patient with an angiomyolipoma. Note the diffuse involvement of the right kidney with an angiomyolipoma. Observe solid and fat density which is characteristic of angiomyolipomas. Abdominal CT scanning is positive in over 75% of patients. |
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Figure 3
CT or MRI scanning of the brain is recommended at least once in the lifetime of all S-LAM patients to rule out findings of subclinical TSC such as cortical tubers, subependymal nodules or subependymal giant cell astrocytomas.
CT scan of the head in two patients with tuberous sclerosis. Subependymal nodules are present in panel a. Cortical tubers are present in panel b. |
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Fig. a
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Fig. b
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Figure 4
Pathological features of LAM. Normal lung tissue with type II cells stained with antibody to surfactant protein A is shown. In panel b, an alveolar septal wall is expanded with spindle shaped and Epithelioid LAM cells. HMB 45 staining is shown in panel c. Cystic remodeling of the pulmonary parenchyma is shown in panel d. |
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Fig. a
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Fig. b
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Fig. c
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Fig. d
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