About Lymphangioleiomyomatosis (LAM)

Defining LAM Symptoms of LAM
Diagnosing LAM Stages of LAM
Milestones in LAM LAM & TSC







Significant strides have been made in understanding, diagnosing and treating symptoms and complications of LAM. Still, there is an urgent need to:

  • Increase awareness about LAM in the medical and lay communities;
  • Ensure that women get an early and proper diagnosis;
  • Dedicate research funding to find a safe and effective treatment for LAM, and ultimately, a cure.

Facts About LAM

  • Symptoms may include shortness of breath, collapsed lung, chest pain, cough, and/or fatigue.
  • Up to 40% of women with LAM have a benign kidney tumor called angiomyolipoma.
  • LAM does not usually appear on an x-ray. A high-resolution CT scan of the chest, and often the abdominal area, is required for accurate diagnosis.
  • LAM results in progressive destruction of healthy lung tissue caused by cyst formation and abnormal growth of smooth muscle cells not usually found in the lungs.
  • Lung capacity progressively declines, sometimes resulting in the need for supplemental oxygen.
  • Women often go undiagnosed for years, and are frequently misdiagnosed with asthma, bronchitis, or emphysema.
  • The discovery of a genetic link between LAM and tuberous sclerosis (TS) leads scientists to estimate that more than 250,000 women worldwide are unaware they have LAM.
  • Since LAM occurs almost exclusively in women, the disease is thought to be hormone-related.
  • It is thought that pregnancy may accelerate the disease.


Neither The LAM Foundation nor any staff member is qualified or intended to serve as a source of medical advice. All material contained or referenced on this website, including health- or medical-related materials, is for informational purposes only. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition.

The LAM Foundation attempts to verify the accuracy of information regarding LAM Clinics and health care providers prior to posting on this website. The Foundation does not guarantee and is not responsible for the accuracy of information or the quality of medical care received at any institution, clinic, or by a medical provider listed on our website. The LAM Foundation is not liable for any damages that may result from the use of this site.

If you think you may have a medical emergency, call your doctor or 911 immediately.