LAM Patient Benefit Grant Program

The LAM Foundation welcomes you to join us in Los Angeles, CA at our first-ever Patient Benefit Conference, an innovative meeting where patients, scientists, clinicians and innovators will collaborate to identify science-driven solutions to important mental and physical health issues that LAM patients have identified as most important and relevant to them.

The Patient Benefit Conference will include a mix of patient presentations, didactic sessions and solutions-oriented workshops. Participants who devise promising ideas for new pilot studies or products will be encouraged to submit proposals for funding ($5,000-$40,000 grants) via the LAM Patient Benefit Grant Program. To register and learn more about the Patient Benefit Conference, click here.

Mission of the Patient Benefit Grant Program
To fund proposals that have the potential to result in present-day solutions that have a positive impact on the diagnosis, care or quality of life of patients with LAM.

Guidelines

  • Patient Benefit Grant awards are restricted to projects that propose solutions that will benefit patients in five years or less.
  • Patient Benefit Grant awards provide one year of funding, and range from $5,000 to $50,000.
  • Candidates must have appropriate experience/expertise. Proposals are welcome from all professionals, from engineers, to respiratory therapists, physicians and scientists.
  • Investigators of all nationalities are eligible, but candidates must possess visas that allow for completion of the proposed project at the initiating organization.

Publications
Publications based on any study or research done during the period of support should acknowledge the support of The LAM Foundation, and a reprint should be sent to The LAM Foundation office. Periodic progress reports are required and must be completed to assist the Foundation in shaping future policies with respect to its award program.

Format:

  1. The Proposed Research section of the online grant application for all LAM awards is limited to 10 pages, not including references and figures.
  2. Basic science and clinical proposals should follow the format listed below:
    a. Hypotheses and specific aims
    b. Literature review, preliminary data
    c. Research plan; experimental methods
    d. Significance, importance
  3. Innovative product proposals should follow the format listed below:
    a. Description of program/project including:
    - Description of product aims
    - Brief explanation of this program/project will provide a LAM patient benefit in 5 years or less
    - Describe how your project was designed. Site the best practices or theory of change involved.
    - Time table for implementation and duration of the program/project
    b. List the collaborators of this program/project and describe their roles.
    c. What are the strengths that your team is positioned to offer to address this challenge or need?
    d. Describe the transformational impact you expect to achieve with this grant?
    e. Describe how success will be measured.
    f. Describe the risks involved in your project and the risk mitigation strategies you anticipate employing.
    g. What kind of technical assistance do you anticipate needing to accomplish your goals?

Factors Considered in Evaluation of Applications
Applications are reviewed by a subcommittee of The LAM Foundation Scientific Advisory Board.
Factors considered when selecting awardees are:

  1. Scientific or clinical merit of the research or product proposal.
  2. Relevance to topics identified by LAM patients as their top priority and discussed at the Patient Benefit Conference as outlined here:
    • New imaging technologies to quantify the volume of cysts in the lungs or quantify other lung changes as a means of measuring LAM progression, or assessing treatment response.
    • Identification of new predictive and prognostic biomarkers for LAM; development of a LAM-specific severity scale and studies to further define the various disease-specific phenotypes which can impact the natural history as well as the treatment response among patients with LAM.
    • Creation of patient tools for tracking disease progression and communicating effectively with their care team – online apps, home spirometry, patient reported outcomes, etc.
    • Improvements in oxygen therapy and technology, enhanced understanding of the impact of shortness of breath and chest pain on the quality of life of LAM patients and the role of exercise in LAM patients.
    • Development of tools to help LAM patients cope with anxiety, fear, and depression.
    • New means to address the nature of fatigue in LAM and the potential links to tumor burden and sleep disorders.
  3. Cost efficiency (see below*)
  4. Expertise and commitment of applicant
  5. Research environment

*As the amount of money is limited and the number of proposal we would like to fund will clearly exceed our resources, we ask that applicants hone budgets to amounts absolutely required to complete projects. Cost efficiency will be considered along with scientific merit in all funding decisions.

Examples of allowed costs:

  • Technician or fellow effort
  • Coordinator effort
  • Supplies, reagents, external vendor fees
Examples of costs that are discouraged:
  • PI effort
  • Travel