LAM Science Forum: LAM Tissue Donors Participate in Building on Discoveries in Mouse Models to Advance our Understanding of LAM

Stephen Hammes, MD, PhD 

Professor, Department of Medicine, Endocrine/Metabolism 

Vice Chair for Research, Department of Medicine 

Professor, Department of Pharmacology & Physiology 

Professor, Department of Pathology & Laboratory Medicine 

University of Rochester Medical Center, Rochester, NY 



Dr. Hammes received a B.A. in Chemistry from Cornell University, followed by an M.D. and a Ph.D. in Immunology and Microbiology from Duke University.  Dr. Hammes then moved to the University of California in San Francisco, where he completed an internship and residency in General Medicine, followed by a fellowship in Endocrinology.  In 1999, Dr. Hammes joined the faculty at the University of Texas Southwestern Medical Center in Dallas, where he was a W.W. Caruth Scholar in Biomedical Research. Dr. Hammes moved to the University of Rochester in 2009 to become the Louis S. Wolk Distinguished Professor of Medicine and the Chief of the Division of Endocrinology, Diabetes, and Metabolism. He currently also holds the position of Vice-Chair for Research and Academic Affairs.   Dr. Hammes is interested in steroid production and steroid signaling in female and male reproductive tracts as well as in steroid-sensitive tumors. He is interested in both the positive and negative effects of androgens in the ovary, with a focus on the pathophysiology and treatment of Polycystic Ovary Syndrome (PCOS). In addition, Dr. Hammes studies how androgens and other signals promote prostate cancer proliferation. Finally, Dr. Hammes is interested in the origins and pathophysiology of lymphangioleiomyomatosis.  Dr. Hammes has been the Editor-in-Chief of the journals “Molecular Endocrinology” and “Endocrinology” and is a member of the American Society for Clinical Investigation.


Kathryn Wikenheiser-Brokamp, MD, PhD 

Pathologist and Researcher, Divisions of Pathology and Pulmonary Biology 

Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 

Associate Professor, Department of Pathology & Laboratory Medicine 

Associate Director, Medical Scientist Training Program 

University of Cincinnati, Cincinnati, OH 


Dr. Wikenheiser-Brokamp received a Bachelor of Science Degree in Mathematics/Natural Science with a Minor in Education from the University of Mary in Bismarck, ND, followed by her M.D. and Ph.D. degrees in Medicine and Development Biology at the University of Cincinnati.  She then moved to Washington University in St. Louis, MO where she completed residency training in Pathology including a fellowship in laboratory research.  In 2003, Dr. Wikenheiser-Brokamp returned to Cincinnati where she developed her independent research program and clinical expertise in pulmonary pathology at the University of Cincinnati and Children’s Hospital Medical Center. Dr. Wikenheiser-Brokamp’s research focuses on understanding the mechanisms driving lung disease. She is also an avid teacher with multiple leadership roles in training physician scientists. Her commitment to excellence in education is recognized by 10 teaching awards. Dr. Wikenheiser-Brokamp became involved in LAM research shortly after returning to Cincinnati working closely with pulmonologists Drs. Frank McCormack and then Nishant Gupta to establish safe and effective approaches to LAM diagnosis, conduct research to further our understanding of LAM development and progression,  and establish clinical guidelines for LAM diagnosis and management.

She has served on the LAM Foundation Scientific Advisory Board since 2015 and evaluates grant proposals aimed to promote further advancements in our understanding of LAM and care of LAM patients. Dr. Wikenheiser-Brokamp is passionate about fully understanding lung disease in patients in the clinic and then using patient derived tissues and animal models to discover underlying mechanisms of disease to identify novel approaches to diagnose, predict outcomes and treat patients. Dr. Wikenheiser-Brokamp has extensive experience and enjoys working with multidisciplinary teams with different expertise and skill sets to advance clinical medicine. She is motivated by the patients she treats and strives to team with patients to advance discoveries with potential to improve the lives of patients and their families living with lung disease.

Exercise & LAM: What Do We Know?

Mary Beth Brown, PT, PhD 

Associate Professor, Director of Research 

Division of Physical Therapy 

Department of Rehabilitation Medicine 

University of Washington School of Medicine 




Dr. Brown is an Associate Professor in the Department of Rehabilitation Medicine, Division of Physical Therapy, at the University of Washington. Her research is focused on exercise responses in patients and rodent models of pulmonary disease. Her past research helped to establish exercise recommendations for patients with pulmonary arterial hypertension and cystic fibrosis.  

After attending The LAM Foundation Patient Benefit Conference in 2017, it became clear there was an urgent need for research on exercise and fatigue in LAM. Dr. Brown is currently leading a study to examine the impact of a home-based mobile health exercise program for patients with LAM, and to characterize skeletal muscle and skeletal muscle response to exercise in LAM.