Pat Rubadeau talks about the top twenty reasons why she likes best about LAMposium.
In an ongoing series of studies in our lab over the past 4 years, funded in part by a generous LAM Foundation Postdoctoral Fellowship to Issam, we set out to define the metabolic changes that occur when mTOR is activated both physiologically in normal cells and pathologically, upon loss of function of the tuberous sclerosis complex (TSC) genes, which underlies the development of LAM. These studies, which Issam lead in collaboration with two other postdoctoral fellows from the lab, Jessica Howell and Gerta Hoxhaj, made an important new discovery regarding the cellular functions of mTOR that contribute to its role in promoting cell growth. In two separate papers in Science1, 2, the most recent being published this February, we describe two previously unknown functions for mTOR that stimulate the synthesis of nucleotides, the building blocks for our genetic material RNA and DNA.
BY CAROL SEE
Every woman has a story about her path to a LAM diagnosis. My story actually began with a diagnosis of mononucleosis. In late 2011, I was feeling so tired and weak that I could barely stand up. After a series of blood tests, my doctor sent me to the hospital, but the ER sent me home after the mono diagnosis. At age 48, jokes ensued.
But my doctor was convinced something additional was wrong, and after further testing and consultation with an endocrinologist, he diagnosed me with adrenal insufficiency, aka Addison’s disease. The abdomen CT he had ordered showed some lung nodules that he wanted to re-check in three months.