Journeys

Journeys is the official newsletter for The LAM Foundation. It is a publication distributed by mail to patients, contributors, health care providers and researchers. Published biannually, the goal of Journeys is to keep the community informed about the Foundation's activities and accomplishments.

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RLDC•2016•LAMposium Highlights


We are less than a month away from the largest Rare Lung Diseases Research Conference to ever take place in the United States. And it is all happening September 22 – 25 at the Northern Kentucky Convention Center, directly across the river from Cincinnati, Ohio. The LAM Foundation is partnering with the Rare Lung Diseases Consortium to host the RLDC•2016•LAMposium. Researchers and clinicians who are studying or treating over 17 rare lung diseases will gather with us to share the latest research updates and discuss how to properly diagnose and treat these rare lung diseases.

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Tags: LAMposium

Add Your Personal Touch to this Year’s LAM Quilts


It's Quilt Time X

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ATTENTION LAM ADVOCATES: We need your help!


The Senate is scheduled to debate the National Defense Authorization Act for fiscal year 2017 (S. 2943), which includes two provisions that would significantly restrict and possibly even eliminate funding for the medical research programs conducted by the Department of Defense (DoD), including research funded by the Tuberous Sclerosis Complex Research Program (TSCRP).

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Tags: Advocacy TSCRP

The LAM Foundation Attends the American Thoracic Society Conference


The American Thoracic Society (ATS) held its international conference May 13- 18 in downtown San Francisco. Members of The LAM Foundation staff, along with expert LAM researchers and clinicians, were in town sharing LAM awareness and educating other lung professionals on the symptoms and signs and how to diagnose LAM.

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Tags: ATS Educational Events

Highlights from the Million Dollar Bike Ride


Not only did our Easy Breathers brave the cold rainy weather to cross the finish-line, they also hit their goal of raising $50,000 for LAM Research. Because they hit their goal, UPenn Orphan Disease Center will match those funds, dollar for dollar. Now two LAM researchers can receive grants to further their research studies!

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Tags: Community Events MDBR

The Twenty Best Things About LAMposium


Pat Rubadeau talks about the top twenty reasons why she likes best about LAMposium. 

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Tags: LAMposium

Join us at the American Thoracic Society Conference in San Francisco


The American Thoracic Society (ATS) is hosting their annual conference in San Francisco May 13 – 18. Pulmonary, critical care, and sleep professionals who are members of the ATS will gather for educational seminars, workshops and exhibitions. The LAM Foundation will also be there and would like you to join us as we promote LAM awareness by educating lung professionals about the symptoms and signs of LAM, diagnostics, treatment and research advances.

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Tags: ATS Educational Events

A Million Things to Do at the Million Dollar Bike Ride


We are just a week away from the starting line at the Million Dollar Bike Ride. The LAM Easy Breathers Cycling Team is 42 riders strong and working hard to raise money for LAM research. If you live near Philadelphia or are in town, check out some of the activities you may want to attend. And of course you do not need to be in Philadelphia to take part in all of the festivities surrounding the event!

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The LAM Story told by Francis Collins, MD, PhD, Director of the NIH


Director of the NIH, Francis Collins, MD, PhD, opens a Rare Disease Day Conference at the NIH with the story about how the LAM Community came together to lead the way to the FDA approval of Rapamune for the treatment of LAM.

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Tags: NIH Rare Disease Day

A new function of mTOR with implications for LAM cell growth and, perhaps, treatment


In an ongoing series of studies in our lab over the past 4 years, funded in part by a generous LAM Foundation Postdoctoral Fellowship to Issam, we set out to define the metabolic changes that occur when mTOR is activated both physiologically in normal cells and pathologically, upon loss of function of the tuberous sclerosis complex (TSC) genes, which underlies the development of LAM. These studies, which Issam lead in collaboration with two other postdoctoral fellows from the lab, Jessica Howell and Gerta Hoxhaj, made an important new discovery regarding the cellular functions of mTOR that contribute to its role in promoting cell growth. In two separate papers in Science1, 2, the most recent being published this February, we describe two previously unknown functions for mTOR that stimulate the synthesis of nucleotides, the building blocks for our genetic material RNA and DNA.

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