Grant Opportunities

IN-CYCLE GRANT OPPORTUNITY INFORMATION

Letter of Intent

The first step in the process of a grant application to The LAM Foundation is to submit a Letter of Intent (LOI). The submission of an LOI is required for each grant category. An applicant must submit an LOI in order to submit a grant application.

Application Timeline for In-Cycle Grants

With the exception of Travel Grants, The LAM Foundation requires all applicants to submit their LOI using the online application form available at our grant website (Foundant Technologies - Grant Lifecycle Manager (GLM).

Note: Applicants must create a profile and be logged in to GLM in order to access The LAM Foundation’s LOI Form. To aid applicants in navigating our online grant system, we offer an 11-minute video tutorial by clicking here.

Inquiries or technical issues regarding GLM and the online application process should be directed to GLM’S customer support:
Toll Free Phone: 877-297-0043 option #2
Email: support@foundant.com

Collaboration with Tuberous Sclerosis Alliance in Research Funding

The LAM Foundation has historically collaborated with the Tuberous Sclerosis Alliance to fund projects that fulfill the research mission of both organizations. You will be asked if you have or will be submitting your project to the Tuberous Sclerosis Alliance for funding in this grant cycle.

Grant Application

If your LOI is approved, The LAM Foundation will invite you to submit a full grant application. Click the following link for information and instructions regarding the submission of a grant application.

For information about The LAM Foundation’s in-cycle grant application process or requirements, please contact Judy Sheridan, Grant and Research Manager at jsheridan@thelamfoundation.org.


In-Cycle Research Grant Categories:

Pilot and Feasibility Grantplus

Funding Level: Maximum of $50,000 may be requested.
Period: Up to 1 year of support is available.

The objective of this grant is to provide funds to encourage the development and testing of new hypotheses and/or new methods in research areas relevant to LAM. Proposed work must be hypothesis generating or hypothesis testing, reflecting innovative approaches to important questions in LAM research or development of novel methods, and providing sufficient preliminary data to justify the Foundation’s support. Results from Pilot and Feasibility Grants should lead to the submission of applications for funding from other agencies (i.e. NIH). At the conclusion of the funding term, applicants are expected to apply for further funding by other mechanisms or from outside agencies. The award is not intended to support continuation of programs begun under other granting mechanisms.

Career Development Research Grantplus

Funding Level: Maximum of $60,000 per year may be requested.
Period: Up to 3 years of support is available. Any funds remaining at the end of each year must be returned to the Foundation unless outlined in your originally submitted project budget or given prior approval.

The objective of this grant is to provide support for postdoctoral research fellows who are starting their research careers and are working in the laboratories of established researchers or conducting research with the mentorship of established researchers. In addition, this grant category is intended to provide support for postdoctoral research fellows or investigators with less than three years in an faculty position who intend to pursue a career in LAM research. Applications will be accepted from candidates holding an M.D., Ph.D. or equivalent degrees who are interested in conducting basic science, clinical research related to LAM. Applicants must indicate a commitment to LAM-related research by focusing 50% of their time to LAM in research or clinical practice. More than 50% of funds must be used for salary support. The balance of the funds may be used for fringe benefits, supplies or animal costs. No overhead or indirect costs are provided.

Established Investigator Research Grantplus

Funding Level: Maximum of $50,000 per year may be requested.
Period: Up to 3 years. This award may be condensed to two years should the investigator request it. Any funds remaining at the end of each year must be returned to the Foundation unless outlined in your originally submitted project budget or given prior approval.

The objective of this grant is to provide funds to faculty level investigators for technician support and supplies to encourage the development of new information that contributes to the understanding of the basic biology of LAM expression, and the pathogenesis/management of LAM. In addition, consideration will be given to those projects that provide insight into the development of information that may contribute to new therapies for LAM. All proposals must be hypothesis generating or hypothesis testing and provide sufficient preliminary data to justify The LAM Foundation’s support.

Travel Grantplus

Funding Level: $1,000

The LAM Foundation sends out a “Call for Abstracts” prior to certain LAM International Research Conferences. Abstracts will be reviewed by the conference organizers and members of the Scientific Advisory Board. Platform Presentations will be selected from submitted abstracts based on scientific merit and thematic considerations. A travel grant will be awarded to those selected as Platform Presenters. Notification of acceptance and selection for presentation will be issued to the submitting author via email. This will provide time for presenters to register for the conference and allow travel grant awardees to make airline reservations at least 3 weeks in advance.



OUT-OF-CYCLE GRANT OPPORTUNITIES

The LAM Foundation also considers proposals for clinical trials, bridge funding and other special projects.

Please contact Judy Sheridan, Grants and Research Manager, at jsheridan@thelamfoundation.org for information about the Foundation's out-of-cycle grant opportunities.

UPENN Orphan Disease Center Million Dollar Bike Ride Grantplus

2017 Million Dollar Bike Ride Pilot Grant Program

The Orphan Disease Center (ODC) at the University of Pennsylvania invites you to participate in the 2017 Million Dollar Bike Ride Pilot Grant Program. The program is now open and offering 33 different research grant opportunities focusing on 23 different rare diseases. The LAM Foundation and Easy Breathers Cycling Team were represented in the 2017 Million Dollar Bike Ride and raised money to fund two $50,600 Pilot Grants for LAM research. This RFA is open to the international community. All individuals holding a faculty‐level appointment at an academic institution or a senior scientific position at a non-profit institution or foundation are eligible to respond to this RFA.

For more details about this grant program, rare disease focus areas and how to apply, please visit the ODC website. Letters of Interest (LOIs) are due no later than Monday, September 18, 2017 by 8pm EST. Please refer to PENN Medicine Orphan Disease Center website for instructions on LOI submission.

Please contact:
Samantha Charleston
Assistant Director
Orphan Disease Center
University of Pennsylvania
Phone: 215-573-6822
Email:
Website: www.milliondollarbikeride.org

LAM Patient Benefit Grant Programplus

On November 10 & 11, 2017 in Los Angeles, CA., The LAM Foundation will host the Patient Benefit Conference, an innovative meeting where patients and experts will collaborate to identify science-driven solutions to the most important mental and physical health issues LAM patients face every day, and develop plans to tackle those that can potentially be solved in less than five years.

The LAM Foundation Patient Benefit Grant Program (PBGP) has been created for the purpose of awarding grants for the most promising ideas generated at the conference. Click here to donate to the Patient Benefit Grant Program. Funds raised during the Breath of Hope Gala during the conference will also support the PBGP. The RFA for the grant funds will be released in early September 2017. Click here to learn more about the focus area for discussion conference, who should attend and how you can participate.

Mission of the Patient Benefit Grant Program
To fund proposals that have the potential to result in present-day solutions that have a positive impact on the diagnosis, care or quality of life of patients with LAM.

Guidelines

  • Patient Benefit Grant awards are restricted to projects that propose solutions that will benefit patients in five years or less.
  • Patient Benefit Grant awards provide one year of funding, and range from $5,000 to $50,000.
  • Candidates must have appropriate experience/expertise. Proposals are welcome from all professionals, from engineers, to respiratory therapists, physicians and scientists.
  • Investigators of all nationalities are eligible, but candidates must possess visas that allow for completion of the proposed project at the initiating organization.

Publications
Publications based on any study or research done during the period of support should acknowledge the support of The LAM Foundation, and a reprint should be sent to The LAM Foundation office. Periodic progress reports are required and must be completed to assist the Foundation in shaping future policies with respect to its award program.

Format:

  1. The Proposed Research section of the online grant application for all LAM awards is limited to 10 pages, not including references and figures.
  2. Basic science and clinical proposals should follow the format listed below:
    a. Hypotheses and specific aims
    b. Literature review, preliminary data
    c. Research plan; experimental methods
    d. Significance, importance
  3. Innovative product proposals should follow the format listed below:
    a. Description of program/project including:
    - Description of product aims
    - Brief explanation of this program/project will provide a LAM patient benefit in 5 years or less
    - Describe how your project was designed. Site the best practices or theory of change involved.
    - Time table for implementation and duration of the program/project
    b. List the collaborators of this program/project and describe their roles.
    c. What are the strengths that your team is positioned to offer to address this challenge or need?
    d. Describe the transformational impact you expect to achieve with this grant?
    e. Describe how success will be measured.
    f. Describe the risks involved in your project and the risk mitigation strategies you anticipate employing.
    g. What kind of technical assistance do you anticipate needing to accomplish your goals?

Factors Considered in Evaluation of Applications
Applications are reviewed by a subcommittee of The LAM Foundation Scientific Advisory Board.
Factors considered when selecting awardees are:

  1. Scientific or clinical merit of the research or product proposal.
  2. Relevance to topics identified by LAM patients as their top priority and discussed at the Patient Benefit Conference as outlined here:
    • New imaging technologies to quantify the volume of cysts in the lungs or quantify other lung changes as a means of measuring LAM progression, or assessing treatment response.
    • Identification of new predictive and prognostic biomarkers for LAM; development of a LAM-specific severity scale and studies to further define the various disease-specific phenotypes which can impact the natural history as well as the treatment response among patients with LAM.
    • Creation of patient tools for tracking disease progression and communicating effectively with their care team – online apps, home spirometry, patient reported outcomes, etc.
    • Improvements in oxygen therapy and technology, enhanced understanding of the impact of shortness of breath and chest pain on the quality of life of LAM patients and the role of exercise in LAM patients.
    • Development of tools to help LAM patients cope with anxiety, fear, and depression.
    • New means to address the nature of fatigue in LAM and the potential links to tumor burden and sleep disorders.
  3. Cost efficiency (see below*)
  4. Expertise and commitment of applicant
  5. Research environment

*As the amount of money is limited and the number of proposal we would like to fund will clearly exceed our resources, we ask that applicants hone budgets to amounts absolutely required to complete projects. Cost efficiency will be considered along with scientific merit in all funding decisions.

Examples of allowed costs:

  • Technician or fellow effort
  • Coordinator effort
  • Supplies, reagents, external vendor fees
Examples of costs that are discouraged:
  • PI effort
  • Travel