Grant Opportunities

The LAM Foundation offers grant opportunities for researchers interested in studying lymphangioleiomyomatosis. Learn about our grant opportunities below.

Grants and Research Awardsplus

The LAM Foundation offers the following research awards and grants:

  • Career Development Awards provide a maximum of $50,000 per year, renewable for up to two additional years).
  • More than 50% of the funds must be used for fellow salary support (the maximum fellow salaries allowed are based on NIH guidelines for postdoctoral fellows).
  • The balance of the funds may be used for fringe benefits, supplies or animal costs.
  • No overhead or indirect costs are provided.
  • Funds not spent are to be returned to The LAM Foundation at the end of each funding year.
  • Applications must describe how the grant will advance the investigator’s career.
  • Established Investigator Awards provide a maximum of $50,000 per year, renewable for up to two additional years. This award may be condensed to two years should the investigator request it. The terms of this award are identical to the Career Development Award except that the LAM Established Award allows faculty-level investigators to receive funding for technician support and supplies.
  • Pilot Project Awards provide up to $25,000 and are available for the initiation of innovative research projects.
  • Other awards. The LAM Foundation also considers proposals for clinical trials, bridge funding and other special projects.

Who Can Apply?plus

Candidates for The LAM Foundation awards must have:

  • At least two years of research experience
  • An MD, PhD or equivalent degree
  • Access to perform work in a laboratory with established expertise in smooth muscle biology, genetics of tuberous sclerosis or other LAM-related areas
  • Applications are welcomed of all nationalities, but candidates working in the USA must possess a visa that allow completion of the proposed project in the original laboratory

Funding Cycleplus

Investigators who wish to apply for funding from The LAM Foundation must submit a Letter of Intent (LOI) by June 15th using our online application system.

  • April 15 – The Foundation’s grant website will open to begin the Letter of Intent process.
  • June 15 - Deadline to submit Letter of Intent (LOI) by 11:59 PM CDT.
  • July 15 - The LAM Foundation invites select investigators who offer competitive projects to submit full proposals
  • September 15 - Deadline to submit full LAM grant proposal by 11:59 PM CDT.
  • December 30 - Applicants notified of grant selection
  • January - Funding begins

Online Applicationplus

For all grant programs, The LAM Foundation only accepts applications via its online application system.

The online process includes all stages of the application process:

  • Initial letters of intent
  • Full applications
  • Follow-up grant reports

NOTE: The LAM Foundation does not process paper submissions of any of these documents.

Letters of Intent (LOIs) are required. Letters of Intent are reviewed by members of the Scientific Advisory Board (SAB) for scientific merit and alignment with The LAM Foundation mission.

Deadline to submit:

June 15 (11:59 PM CDT)

Response to your letter of intent

The LAM Foundation extends invitations to submit full proposals to investigators who have submitted LOIs describing projects considered to be competitive after July 15.

Grant Proposalplus

Deadline to submit:

September 15 (11:59 PM CDT)

Formatting the Online Grant Application

The Proposed Research section of the online grant application for all LAM awards is limited to six pages, excluding references, no exceptions.

All proposals should follow the following format:

  1. Hypotheses and specific aims
  2. Literature review, preliminary data
  3. Research plan; experimental methods
  4. Significance, importance

Grant and Research Selection Process

A primary objective of The LAM Foundation’s Research Program is to elevate LAM science to levels that are competitive for more substantial funding from federal sources.

All Grant and Research Proposals submitted are:

  • Peer-reviewed
  • Ranked by The LAM Foundation’s Scientific Advisory Board
  • Voted on by The LAM Foundation’s Board of Directors

Examples of competitive LAM proposals include:

  • Focus on the genetic regulation of smooth muscle growth or the development of a smooth muscle cell line that is representative of the LAM lesion
  • Mechanistic, hypotheses-driven approaches of all types
  • Formalin-fixed LAM tissues, dispersed LAM lung cells, genetic probes and other reagents

PLEASE NOTE: When submitting Grant and Research Proposals:

  • All putative LAM cell and animal models used in The LAM Foundation proposals must be carefully validated.
  • Cell lines derived from human tissues must be clonally isolated and genotyped to demonstrate the presence of mutations in both alleles of TSC1 or TSC2, both at the birth of the cell line and in the hands of the applicant.
  • Dr. David Kwiatkowski at Brigham & Women’s Hospital will perform the genotyping analysis without charge.
  • Use of clonal cell lines from rodents, such as ELT3 and ERC15 cells, to confirm results is encouraged.
  • Proposals that include poorly characterized cell lines or animal models will be returned without review.

Selection Criteriaplus

Applications are reviewed by The LAM Foundation Scientific Advisory Board who considers the following factors when selecting awardees:

  • Merit of the research proposal
  • Relevance of the project to LAM
  • Applicant's experience, publications, letters of recommendation, and potential for making a significant contribution to LAM research
  • Proposed research environment and the commitment of the applicant and/or the fellowship sponsor to LAM research
  • Likelihood that successful completion of the project will lead to a sustainable LAM research program

Collaboration with Tuberous Sclerosis Alliance in Research Funding

The LAM Foundation has historically collaborated with the Tuberous Sclerosis Alliance to fund projects that fulfill the research mission of both organizations. You will be asked if you have or will be submitting your project to the Tuberous Sclerosis Alliance for funding in this grant cycle.

Publishing Researchplus

Publications based on any study or research done during the period of support should always acknowledge the support of The LAM Foundation. A reprint should be sent to The LAM Foundation office.

Change in Research or Employment Statusplus

Transfer between institutions or departments or shifts of budgetary funds after grants or research funds have been awarded require prior approval by The LAM Foundation.

To begin the grant application process, please click here.

To learn more about The LAM Foundation Research Awards, contact Judy Sheridan, Grants and Research Manager, at 513.777.6889 or